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00:00:04:18,	00:00:08:14,	Skin hydration is a major concern
00:00:08:14,	00:00:11:02,	for those who are getting older
00:00:11:08,	00:00:14:20,	Their main complain is "my skin is drying out".
00:00:15:00,	00:00:18:09,	We are trying to understand why skin| becomes drier with age.
00:00:18:17,	00:00:22:06,	A lot has been said about epidermal function
00:00:22:06,	00:00:24:14,	and the role of the stratum corneum,
00:00:24:17,	00:00:27:00,	but the role played by the dermis
00:00:27:00,	00:00:29:07,	is rarely discussed.
00:00:29:12,	00:00:31:14,	The dermal structure
00:00:31:16,	00:00:33:11,	and the skins extracellular matrix,
00:00:33:15,	00:00:36:12,	the glycosaminoglycans and the collagen
00:00:36:14,	00:00:40:00,	help to preserve its water content.
00:00:40:02,	00:00:43:16,	This intradermal water plays a major role,
00:00:43:16,	00:00:46:00,	as the dermis is in contact with the epidermis
00:00:45:00,	00:00:46:19,	as the dermis is in contact with the epidermis
00:00:46:20,	00:00:50:09,	and provides it with the water it needs.
00:00:50:22,	00:00:52:17,	It is important to study the epidermis and the dermis.
00:00:51:17,	00:00:55:11,	It is important to study the epidermis and the dermis.
00:00:55:16,	00:01:01:20,	It would be over-simplistic to focus on just one aspect|of the skin when developing cosmetics
00:01:02:03,	00:01:07:11,	The research we have carried out|within our laboratories on reconstructed skin
00:01:07:16,	00:01:12:04,	and in vivo on volunteers
00:01:12:09,	00:01:16:16,	have all helped us establish| that the dermis plays a key role in skin hydration.
